League Leaders - Offense
| Passing Yards | Complete List | |
Sam Howell
|
1. Sam Howell, WAS | 937 |
| 2. Ben Flannigan, NYG | 764 | |
| 3. Tom Brady, CAR | 752 | |
| 4. Kyler Murray, ARI | 626 | |
| 5. Marco Webster, SEA | 602 | |
| Rushing Yards | Complete List | |
Christian McCaffrey
|
1. Christian McCaffrey, CAR | 328 |
| 2. Isiah Pacheco, KC | 298 | |
| 3. Jonathan Taylor, IND | 253 | |
| 4. Saquon Barkley, NYG | 237 | |
| 5. Brian Robinson Jr, WAS | 226 | |
| Receiving Yards | Complete List | |
DeAndre Hopkins
|
1. DeAndre Hopkins, ARI | 298 |
| 2. Dylan Stein, CIN | 262 | |
| 3. Ben Patterson, NYG | 246 | |
| 4. Irv Smith Jr, MIN | 235 | |
| 5. Terry McLaurin, WAS | 221 | |
League Leaders - Defense
| Tackles | Complete List | |
Jamal Adams
|
1. Jamal Adams, SEA | 10 |
| 2. Bobby Wagner, WAS | 9 | |
| 3. Mike Edwards, TB | 8 | |
| 4. Bobby McCain, WAS | 8 | |
| 5. Justin Reid, KC | 8 | |
| Sacks | Complete List | |
Montez Sweat
|
1. Montez Sweat, WAS | 3 |
| 2. Myles Garrett, CLE | 3 | |
| 3. Cole Holcomb, WAS | 3 | |
| 4. DeForest Buckner, IND | 2 | |
| 5. Shaquil Barrett, TB | 2 | |
| Interceptions | Complete List | |
Jevon Holland
|
1. Jevon Holland, MIA | 5 |
| 2. Kamren Curl, WAS | 4 | |
| 3. Brandon Jones, MIA | 4 | |
| 4. William Jackson III, WAS | 3 | |
| 5. Trevon Diggs, DAL | 3 | |