League Leaders - Offense
| Passing Yards | Complete List | |
Ernie Ramsey
|
1. Ernie Ramsey, TEN | 5670 |
| 2. Jalen Hurts, PHI | 5327 | |
| 3. Will Hoover, GB | 5204 | |
| 4. Trevor Lawrence, JAX | 4914 | |
| 5. Kyler Murray, ARI | 4899 | |
| Rushing Yards | Complete List | |
Cameron Quinton
|
1. Cameron Quinton, TB | 2057 |
| 2. Jonathan Taylor, IND | 1544 | |
| 3. Cam Akers, LAR | 1507 | |
| 4. Saquon Barkley, NYG | 1472 | |
| 5. Pat Redmon, BUF | 1412 | |
| Receiving Yards | Complete List | |
Henry Ruggs III
|
1. Henry Ruggs III, ATL | 1762 |
| 2. Marcus Searcy, JAX | 1559 | |
| 3. D.J. Chark Jr, JAX | 1542 | |
| 4. Noah Fant, GB | 1513 | |
| 5. D.J. Moore, CAR | 1476 | |
League Leaders - Defense
| Tackles | Complete List | |
Michael Cobb
|
1. Michael Cobb, DEN | 88 |
| 2. Bill McConnell, KC | 69 | |
| 3. A.J. McClain, CLE | 68 | |
| 4. Kenneth Murray Jr, LAC | 67 | |
| 5. Armon Sheldon, LAR | 67 | |
| Sacks | Complete List | |
Vernon Pollard
|
1. Vernon Pollard, KC | 16 |
| 2. Joey Bosa, LAC | 16 | |
| 3. Ja'Darius Hardwick, ATL | 12 | |
| 4. DeForest Buckner, IND | 12 | |
| 5. Steven Dixon, NYG | 11 | |
| Interceptions | Complete List | |
Shaquill Griffin
|
1. Shaquill Griffin, JAX | 11 |
| 2. Jeremy Chinn, CAR | 11 | |
| 3. Antoine Winfield Jr, TB | 11 | |
| 4. Melo Flowers, IND | 10 | |
| 5. Sean Murphy-Bunting, TB | 10 | |