League Leaders - Offense
| Passing Yards | Complete List | |
Sam Howell
|
1. Sam Howell, WAS | 759 |
| 2. Kyler Murray, ARI | 626 | |
| 3. Marco Webster, SEA | 602 | |
| 4. Dak Prescott, DAL | 532 | |
| 5. Patrick Mahomes, KC | 528 | |
| Rushing Yards | Complete List | |
Isiah Pacheco
|
1. Isiah Pacheco, KC | 298 |
| 2. Jonathan Taylor, IND | 253 | |
| 3. Saquon Barkley, NYG | 233 | |
| 4. Christian McCaffrey, CAR | 217 | |
| 5. Ezekiel Elliott, DAL | 210 | |
| Receiving Yards | Complete List | |
DeAndre Hopkins
|
1. DeAndre Hopkins, ARI | 298 |
| 2. Dylan Stein, CIN | 262 | |
| 3. Irv Smith Jr, MIN | 235 | |
| 4. D.K. Metcalf, SEA | 214 | |
| 5. Chris Godwin, TB | 208 | |
League Leaders - Defense
| Tackles | Complete List | |
Jamal Adams
|
1. Jamal Adams, SEA | 10 |
| 2. Patrick Queen, TB | 8 | |
| 3. Mike Edwards, TB | 8 | |
| 4. Foyesade Oluokun, JAX | 8 | |
| 5. Justin Reid, KC | 8 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, CLE | 3 |
| 2. Cole Holcomb, WAS | 3 | |
| 3. Akeem Davis-Gaither, CIN | 2 | |
| 4. DeForest Buckner, IND | 2 | |
| 5. Shaquil Barrett, TB | 2 | |
| Interceptions | Complete List | |
Jevon Holland
|
1. Jevon Holland, MIA | 5 |
| 2. Brandon Jones, MIA | 4 | |
| 3. Kaiir Elam, BUF | 3 | |
| 4. Kamren Curl, WAS | 3 | |
| 5. William Jackson III, WAS | 3 | |