League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 2849 |
| 2. Gary Bender, DET | 2807 | |
| 3. Andrew Luck, CAR | 2705 | |
| 4. Matt Ryan, ATL | 2548 | |
| 5. Jacoby Brissett, IND | 2477 | |
| Rushing Yards | Complete List | |
Melvin Gordon III
|
1. Melvin Gordon III, LAC | 1181 |
| 2. Todd Gurley II, LAR | 944 | |
| 3. Ezekiel Elliott, DAL | 941 | |
| 4. Chris Carson, SEA | 849 | |
| 5. Jordan Howard, PHI | 821 | |
| Receiving Yards | Complete List | |
Amari Cooper
|
1. Amari Cooper, DAL | 1124 |
| 2. JuJu Smith-Schuster, PIT | 1101 | |
| 3. Christian Kirk, ARI | 1033 | |
| 4. Andy Isabella, ARI | 975 | |
| 5. Parris Campbell, IND | 964 | |
League Leaders - Defense
| Tackles | Complete List | |
Dont'a Hightower
|
1. Dont'a Hightower, NE | 43 |
| 2. Nick Kwiatkoski, NYG | 43 | |
| 3. Adoree' Jackson, TEN | 42 | |
| 4. Byron Murphy Jr, ARI | 41 | |
| 5. Jonathan Jones, NE | 41 | |
| Sacks | Complete List | |
Bud Dupree
|
1. Bud Dupree, DEN | 23 |
| 2. Myles Garrett, CLE | 20 | |
| 3. Aaron Donald, LAR | 19 | |
| 4. Genard Avery, PHI | 18 | |
| 5. Brian Burns, CAR | 17 | |
| Interceptions | Complete List | |
Denzel Ward
|
1. Denzel Ward, CLE | 10 |
| 2. Darnell Savage, GB | 7 | |
| 3. Richard Sherman, SF | 6 | |
| 4. Chidobe Awuzie, DAL | 6 | |
| 5. Justin Simmons, DEN | 6 | |