League Leaders - Offense
| Passing Yards | Complete List | |
Cam Newton
|
1. Cam Newton, CAR | 5727 |
| 2. Shea Patterson, NYJ | 5715 | |
| 3. Jalen Hurts, PHI | 5136 | |
| 4. Patrick Mahomes, PIT | 4933 | |
| 5. Henry Lorello, CIN | 4740 | |
| Rushing Yards | Complete List | |
Dalvin Cook
|
1. Dalvin Cook, MIN | 1512 |
| 2. Joe Mixon, CIN | 1509 | |
| 3. AJ Dillon, SF | 1490 | |
| 4. Derrius Guice, WAS | 1464 | |
| 5. Saquon Barkley, HOU | 1351 | |
| Receiving Yards | Complete List | |
D.J. Moore
|
1. D.J. Moore, CAR | 2335 |
| 2. Robby Anderson, SF | 1917 | |
| 3. Tyreek Hill, KC | 1831 | |
| 4. Josh Boothe, NYJ | 1774 | |
| 5. Margarito McCoy, PIT | 1727 | |
League Leaders - Defense
| Tackles | Complete List | |
Myles Jack
|
1. Myles Jack, JAX | 81 |
| 2. Oscar Gilchrist, BAL | 78 | |
| 3. Anthony Hitchens, TEN | 77 | |
| 4. Jeffrey Okudah, MIA | 75 | |
| 5. Germaine Pratt, LAR | 75 | |
| Sacks | Complete List | |
Carl Lawson
|
1. Carl Lawson, CIN | 26 |
| 2. Adetokunbo Ogundeji, BUF | 24 | |
| 3. Derek Barnett, PHI | 20 | |
| 4. Marcus Davenport, NO | 19 | |
| 5. Nick Bosa, BUF | 19 | |
| Interceptions | Complete List | |
Johnathon Chekwa
|
1. Johnathon Chekwa, BUF | 16 |
| 2. Isaiah Pryor, DET | 11 | |
| 3. Grant Delpit, CAR | 11 | |
| 4. Mack Wilson, WAS | 10 | |
| 5. Parry Nickerson, NYJ | 9 | |