League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 1722 |
| 2. Dwayne Haskins Jr, WAS | 408 | |
| 3. Will Grier, CAR | 0 | |
| 4. Ryan Finley, CIN | 0 | |
| Rushing Yards | Complete List | |
Ryquell Armstead
|
1. Ryquell Armstead, JAX | 209 |
| 2. Darrell Henderson Jr, LAR | 202 | |
| 3. Darwin Thompson, KC | 161 | |
| 4. Kyler Murray, ARI | 154 | |
| 5. Marcus Green, ATL | 84 | |
| Receiving Yards | Complete List | |
T.J. Hockenson
|
1. T.J. Hockenson, DET | 396 |
| 2. Hunter Renfrow, OAK | 227 | |
| 3. Andy Isabella, ARI | 184 | |
| 4. Emanuel Hall, CHI | 161 | |
| 5. Parris Campbell, IND | 148 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 31 |
| 2. Devin Bush, PIT | 25 | |
| 3. Jahlani Tavai, DET | 25 | |
| 4. Nasir Adderley, LAC | 25 | |
| 5. Greedy Williams, CLE | 24 | |
| Sacks | Complete List | |
Brian Burns
|
1. Brian Burns, CAR | 5 |
| 2. Montez Sweat, WAS | 5 | |
| 3. Devin Bush, PIT | 4 | |
| 4. Ed Oliver Jr, BUF | 4 | |
| 5. Quinnen Williams, NYJ | 2 | |
| Interceptions | Complete List | |
Greedy Williams
|
1. Greedy Williams, CLE | 1 |
| 2. Byron Murphy Jr, ARI | 1 | |
| 3. Darnell Savage Jr, GB | 1 | |
| 4. Germaine Pratt, CIN | 1 | |
| 5. Nasir Adderley, LAC | 1 | |