League Leaders - Offense
| Passing Yards | Complete List | |
Andrew Waters
|
1. Andrew Waters, TEN | 5532 |
| 2. Quentin Russo, PIT | 5420 | |
| 3. Sean Mooney, HOU | 4821 | |
| 4. Justin Herbert, LAC | 4796 | |
| 5. Patrick Mahomes, KC | 4741 | |
| Rushing Yards | Complete List | |
Darrell Stephenson
|
1. Darrell Stephenson, ATL | 2274 |
| 2. Antonio Gibson, WAS | 1851 | |
| 3. Nick Chubb, CLE | 1678 | |
| 4. Ezekiel Elliott, DAL | 1605 | |
| 5. Christian McCaffrey, CAR | 1527 | |
| Receiving Yards | Complete List | |
Ricky Conway
|
1. Ricky Conway, TEN | 2622 |
| 2. Alex Reveron, DET | 1865 | |
| 3. Jaylen Waddle, MIA | 1533 | |
| 4. Kyle Pitts, ATL | 1508 | |
| 5. Anthony Schwartz, CLE | 1450 | |
League Leaders - Defense
| Tackles | Complete List | |
Zaven Collins
|
1. Zaven Collins, HOU | 120 |
| 2. Patrick Queen, BAL | 113 | |
| 3. Dexter Bradley, PHI | 112 | |
| 4. Steve Grove, SEA | 107 | |
| 5. Henry Burroughs, SEA | 102 | |
| Sacks | Complete List | |
DeForest Buckner
|
1. DeForest Buckner, IND | 17 |
| 2. Myles Garrett, CLE | 17 | |
| 3. Josh Allen, JAX | 17 | |
| 4. Franklin Dent, CHI | 16 | |
| 5. Isaiah Simmons, ARI | 16 | |
| Interceptions | Complete List | |
Caleb Farley
|
1. Caleb Farley, TEN | 11 |
| 2. Tarvarius Moore, IND | 10 | |
| 3. Dion Meander, WAS | 9 | |
| 4. Richie Grant, ATL | 9 | |
| 5. Lynn Toone, ARI | 9 | |