League Leaders - Offense
| Passing Yards | Complete List | |
Jacob Eason
|
1. Jacob Eason, WAS | 2930 |
| 2. Deshaun Watson, HOU | 2836 | |
| 3. Drew Lock, DEN | 2785 | |
| 4. Max Watts, NO | 2679 | |
| 5. Joe Burrow, BUF | 2516 | |
| Rushing Yards | Complete List | |
Nick Chubb
|
1. Nick Chubb, CLE | 886 |
| 2. Leonard Fournette, LAC | 823 | |
| 3. Jack Johnson, LV | 821 | |
| 4. Tony Pollard, HOU | 784 | |
| 5. Saquon Barkley, NYG | 727 | |
| Receiving Yards | Complete List | |
Mecole Hardman
|
1. Mecole Hardman, DAL | 1045 |
| 2. Tyreek Hill, NO | 1015 | |
| 3. Denzel Mims, WAS | 984 | |
| 4. Darius Slayton, MIA | 962 | |
| 5. Rashawn Carr, MIN | 901 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin Bush
|
1. Devin Bush, PIT | 51 |
| 2. Roquan Smith, CHI | 47 | |
| 3. Carlos Temple, IND | 40 | |
| 4. Deion Jones, ATL | 39 | |
| 5. Logan Wilson, CIN | 39 | |
| Sacks | Complete List | |
Danielle Hunter
|
1. Danielle Hunter, LAC | 11 |
| 2. T.J. Childress, CHI | 10 | |
| 3. Brian Burns, CAR | 9 | |
| 4. Jason Smith, ARI | 8 | |
| 5. Rashan Gary, GB | 8 | |
| Interceptions | Complete List | |
Kevin Byard
|
1. Kevin Byard, CHI | 10 |
| 2. Glenn McPherson, DAL | 8 | |
| 3. Justin Reid, HOU | 7 | |
| 4. Kendall Fuller, NE | 7 | |
| 5. David Andrews, NYG | 7 | |