Weekly Fantasy Leaders - Offense
| Passing Leaders | Complete List | |
Russell Wilson
|
1. Russell Wilson, SEA | 29 |
| 2. Baker Mayfield, CLE | 23 | |
| 3. Justin Fields, CHI | 20 | |
| 4. Trevor Lawrence, JAX | 19 | |
| 5. Kyler Murray, ARI | 10 | |
| Rushing Leaders | Complete List | |
Chase Edmonds
|
1. Chase Edmonds, ARI | 18 |
| 2. Raheem Mostert, SF | 12 | |
| 3. Nick Chubb, CLE | 11 | |
| 4. David Montgomery, CHI | 7 | |
| 5. Kareem Hunt, CLE | 6 | |
| Receiving Leaders | Complete List | |
D.K. Metcalf
|
1. D.K. Metcalf, SEA | 36 |
| 2. Darnell Mooney, CHI | 30 | |
| 3. Albert Okwuegbunam, JAX | 19 | |
| 4. Austin Hooper, CLE | 18 | |
| 5. Quez Watkins, SF | 17 | |
Weekly Fantasy Leaders - Defense
| Defense Leaders | Complete List | |
Roquan Smith
|
1. Roquan Smith, CHI | 16 |
| 2. C.J. Henderson, JAX | 13 | |
| 3. Jeff Okudah, DET | 10 | |
| 4. Bradley Roby, CHI | 10 | |
| 5. Rayshawn Jenkins, JAX | 9 | |
| Kicking Leaders | Complete List | |
Cairo Santos
|
1. Cairo Santos, CHI | 11 |
| 2. Jason Myers, SEA | 9 | |
| 3. Robbie Gould, SF | 5 | |
| 4. Chase McLaughlin, CLE | 3 | |