League Leaders - Offense
| Passing Yards | Complete List | |
Kenny Pickett
|
1. Kenny Pickett, NO | 2192 |
| 2. Malik Willis, BAL | 2133 | |
| 3. Justin Herbert, LAC | 2119 | |
| 4. Scottie Woodard, DET | 2065 | |
| 5. Dom Heyward, GB | 2002 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, IND | 758 |
| 2. Dalvin Cook, MIN | 729 | |
| 3. James Cook, BUF | 666 | |
| 4. Quincy Woodley, CAR | 643 | |
| 5. Breece Hall, NYJ | 598 | |
| Receiving Yards | Complete List | |
Bernie Walker
|
1. Bernie Walker, PHI | 1222 |
| 2. Jameson Williams, DET | 1131 | |
| 3. Chris Olave, NO | 748 | |
| 4. A.J. Stinson, LAC | 701 | |
| 5. Kyle Pitts, ATL | 685 | |
League Leaders - Defense
| Tackles | Complete List | |
Bobby Okereke
|
1. Bobby Okereke, IND | 40 |
| 2. Troy Andersen, ATL | 35 | |
| 3. Trevor Jones, NYG | 35 | |
| 4. Jerome Baker, MIA | 34 | |
| 5. Joe Knott, BAL | 32 | |
| Sacks | Complete List | |
Michael Turner
|
1. Michael Turner, TB | 7 |
| 2. Greg Rousseau, BUF | 7 | |
| 3. Danielle Hunter, MIN | 6 | |
| 4. Josh Sweat, PHI | 6 | |
| 5. George Karlaftis, KC | 5 | |
| Interceptions | Complete List | |
Sterling Blake
|
1. Sterling Blake, CIN | 11 |
| 2. Joe Knott, BAL | 8 | |
| 3. Tanner Muse, DEN | 6 | |
| 4. Jalen Ramsey, KC | 6 | |
| 5. C.J. Gardner-Johnson, PHI | 6 | |