League Leaders - Offense
| Passing Yards | Complete List | |
Justin Herbert
|
1. Justin Herbert, LAC | 772 |
| 2. Malik Cunningham, NE | 752 | |
| 3. Bryan Stringer, NYJ | 666 | |
| 4. Kyler Murray, PIT | 663 | |
| 5. Chris Proctor, MIN | 637 | |
| Rushing Yards | Complete List | |
Bijan Robinson
|
1. Bijan Robinson, ATL | 332 |
| 2. Saquon Barkley, NYG | 319 | |
| 3. Josh Jacobs, LV | 318 | |
| 4. Derrick Henry, TEN | 274 | |
| 5. Isiah Pacheco, KC | 258 | |
| Receiving Yards | Complete List | |
Jonathan Mingo
|
1. Jonathan Mingo, CAR | 337 |
| 2. Chris Olave, NO | 316 | |
| 3. Clifford Franklin, PIT | 314 | |
| 4. Mike Redmond, NYJ | 290 | |
| 5. Brian Trejo, HOU | 290 | |
League Leaders - Defense
| Tackles | Complete List | |
Alex Singleton
|
1. Alex Singleton, DEN | 14 |
| 2. Terrel Bernard, BUF | 13 | |
| 3. Jeremiah Owusu-Koramoah, CLE | 12 | |
| 4. Baylon Spector, BUF | 11 | |
| 5. Jordan Poyer, BUF | 11 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 6 |
| 2. Da'Ron Payne, WAS | 4 | |
| 3. Micah Parsons, DAL | 3 | |
| 4. Trenton Simpson, BAL | 3 | |
| 5. Will McDonald IV, NYJ | 3 | |
| Interceptions | Complete List | |
Donte Jackson
|
1. Donte Jackson, CAR | 4 |
| 2. Ryan Neal, CLE | 4 | |
| 3. Jaire Alexander, GB | 4 | |
| 4. A.J. Terrell Jr, ATL | 3 | |
| 5. Ashtyn Davis, NYJ | 3 | |