League Leaders - Offense
| Passing Yards | Complete List | |
Roy Stevens
|
1. Roy Stevens, CHI | 4287 |
| 2. Jameel Pope, LAR | 4218 | |
| 3. Raymond Proctor, MIN | 3585 | |
| 4. Jimmy Gilliam, HOU | 110 | |
| 5. Adrian Clapp, MIA | 37 | |
| Rushing Yards | Complete List | |
Taylor Hicks
|
1. Taylor Hicks, MIA | 416 |
| 2. Rodriguez Carey, HOU | 211 | |
| 3. Jawaun Smallwood, MIA | 77 | |
| 4. B.J. Taylor, JAX | 70 | |
| 5. Roy Stevens, CHI | 51 | |
| Receiving Yards | Complete List | |
Jaylun Buck
|
1. Jaylun Buck, PHI | 2261 |
| 2. Tevita Bartell, SEA | 1314 | |
| 3. Heath Evans, LAC | 1093 | |
| 4. Morris Dyer, CHI | 1052 | |
| 5. Rob Sheard, CIN | 825 | |
League Leaders - Defense
| Tackles | Complete List | |
Aleon Hendrix
|
1. Aleon Hendrix, LAR | 78 |
| 2. Jaden Perkins, DET | 65 | |
| 3. Dre Foster, DEN | 57 | |
| 4. Raymond Godfrey, ARI | 49 | |
| 5. Vaughn Webber, MIN | 45 | |
| Sacks | Complete List | |
Dexter Nicks
|
1. Dexter Nicks, BUF | 8 |
| 2. Ryan Fernandez, LAC | 8 | |
| 3. Dre Foster, DEN | 6 | |
| 4. DeMar Pounds, TEN | 4 | |
| 5. Delafonta Tripplett, ARI | 4 | |
| Interceptions | Complete List | |
Dre Foster
|
1. Dre Foster, DEN | 5 |
| 2. Shyquawn Carter, NE | 4 | |
| 3. Jarred Fassitt, NYJ | 3 | |
| 4. Lamarcus Artmore, OAK | 3 | |
| 5. Roman Fields, PIT | 3 | |