League Leaders - Offense
| Passing Yards | Complete List | |
Tua Tagovailoa
|
1. Tua Tagovailoa, NO | 2497 |
| 2. Jalen Hurts, CHI | 2375 | |
| 3. Justin Herbert, SF | 2068 | |
| 4. Joe Burrow, DET | 1732 | |
| 5. Tyler Huntley, LAC | 602 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, DAL | 626 |
| 2. Anthony McFarland Jr., PIT | 540 | |
| 3. Darrynton Evans, ATL | 412 | |
| 4. J.K. Dobbins, GB | 349 | |
| 5. Eno Benjamin, LAR | 296 | |
| Receiving Yards | Complete List | |
Henry Ruggs III
|
1. Henry Ruggs III, SF | 844 |
| 2. Jalen Reagor, NYG | 556 | |
| 3. Jerry Jeudy, CHI | 404 | |
| 4. K.J. Hamler, PHI | 388 | |
| 5. CeeDee Lamb, ATL | 387 | |
League Leaders - Defense
| Tackles | Complete List | |
Isaiah Simmons
|
1. Isaiah Simmons, PHI | 44 |
| 2. Javelin Guidry, ATL | 33 | |
| 3. Willie Gay Jr., WAS | 29 | |
| 4. Jeffrey Okudah, CLE | 28 | |
| 5. Derrick Brown, LAC | 21 | |
| Sacks | Complete List | |
Willie Gay Jr.
|
1. Willie Gay Jr., WAS | 8 |
| 2. Kenneth Murray, SEA | 6 | |
| 3. Yetur Gross-Matos, CLE | 5 | |
| 4. Markus Bailey, IND | 4 | |
| 5. Carter Coughlin, BAL | 4 | |
| Interceptions | Complete List | |
Khaleke Hudson
|
1. Khaleke Hudson, NYJ | 10 |
| 2. K'Lavon Chaisson, OAK | 5 | |
| 3. Kristian Fulton, LAR | 3 | |
| 4. Grant Delpit, DAL | 3 | |
| 5. Jeffrey Okudah, CLE | 3 | |