League Leaders - Offense
| Passing Yards | Complete List | |
Tony Romo
|
1. Tony Romo, LAR | 2603 |
| 2. Carson Palmer, NYG | 1632 | |
| 3. Byron Leftwich, DAL | 534 | |
| 4. Seneca Wallace, NYJ | 93 | |
| 5. Kyle Boller, CAR | 41 | |
| Rushing Yards | Complete List | |
Justin Fargas
|
1. Justin Fargas, ARI | 655 |
| 2. Larry Johnson, OAK | 574 | |
| 3. Domanick Davis, SEA | 166 | |
| 4. Quentin Griffin, KC | 112 | |
| 5. Lee Suggs, NYJ | 103 | |
| Receiving Yards | Complete List | |
Antonio Gates
|
1. Antonio Gates, ARI | 444 |
| 2. Jason Witten, KC | 436 | |
| 3. Taylor Jacobs, OAK | 378 | |
| 4. Anquan Boldin, WAS | 361 | |
| 5. Dallas Clark, CLE | 320 | |
League Leaders - Defense
| Tackles | Complete List | |
Terence Newman
|
1. Terence Newman, DEN | 32 |
| 2. Troy Polamalu, LAR | 31 | |
| 3. Eugene Wilson, ARI | 30 | |
| 4. Cato June, ARI | 29 | |
| 5. Sammy Davis, GB | 28 | |
| Sacks | Complete List | |
Chris Kelsay
|
1. Chris Kelsay, CAR | 5 |
| 2. Nick Barnett, BAL | 4 | |
| 3. Cory Redding, NO | 3 | |
| 4. Lance Briggs, ARI | 3 | |
| 5. Terrell Suggs, GB | 3 | |
| Interceptions | Complete List | |
Joe Odom
|
1. Joe Odom, WAS | 3 |
| 2. Nick Barnett, BAL | 2 | |
| 3. Troy Polamalu, LAR | 2 | |
| 4. Asante Samuel, ARI | 2 | |
| 5. Sammy Davis, GB | 1 | |