League Leaders - Offense
| Passing Yards | Complete List | |
Desmond Ridder
|
1. Desmond Ridder, BUF | 1177 |
| 2. Matt Corral, DAL | 937 | |
| 3. Kenny Pickett, TEN | 607 | |
| 4. Sam Howell, TB | 467 | |
| 5. Malik Willis, NE | 461 | |
| Rushing Yards | Complete List | |
James Cook
|
1. James Cook, LV | 249 |
| 2. Brian Robinson Jr., TEN | 159 | |
| 3. Kenneth Walker III, BAL | 125 | |
| 4. Breece Hall, SF | 94 | |
| 5. Malik Willis, NE | 73 | |
| Receiving Yards | Complete List | |
Garrett Wilson
|
1. Garrett Wilson, PIT | 484 |
| 2. Skyy Moore, BUF | 340 | |
| 3. Calvin Austin III, CIN | 228 | |
| 4. Chris Olave, ATL | 194 | |
| 5. Drake London, MIA | 190 | |
League Leaders - Defense
| Tackles | Complete List | |
Quay Walker
|
1. Quay Walker, PIT | 15 |
| 2. Kaiir Elam, CHI | 14 | |
| 3. Markquese Bell, MIA | 14 | |
| 4. Derek Stingley Jr., BUF | 14 | |
| 5. Chad Muma, DEN | 14 | |
| Sacks | Complete List | |
Kalon Barnes
|
1. Kalon Barnes, LAR | 4 |
| 2. Boye Mafe, LAR | 3 | |
| 3. Aiden Hutchinson, PHI | 3 | |
| 4. Perrion Winfrey, DAL | 3 | |
| 5. Brandon Smith, JAX | 2 | |
| Interceptions | Complete List | |
J.T. Woods
|
1. J.T. Woods, LAR | 3 |
| 2. Damone Clark, GB | 2 | |
| 3. Andrew Booth Jr, WAS | 2 | |
| 4. Nick Cross, CAR | 2 | |
| 5. Bubba Bolden, ATL | 1 | |