League Leaders - Offense
| Passing Yards | Complete List | |
Tyree Jackson
|
1. Tyree Jackson, TEN | 3191 |
| 2. Kyler Murray, CLE | 3020 | |
| 3. Daniel Jones, LAR | 2677 | |
| 4. Dwayne Haskins, SEA | 1883 | |
| 5. Drew Lock, KC | 24 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, BAL | 926 |
| 2. Miles Sanders, SF | 614 | |
| 3. David Montgomery, ATL | 498 | |
| 4. Darrell Henderson, NYJ | 375 | |
| 5. Damien Harris, CLE | 341 | |
| Receiving Yards | Complete List | |
N'Keal Harry
|
1. N'Keal Harry, HOU | 1591 |
| 2. Parris Campbell, PHI | 1389 | |
| 3. Andy Isabella, NO | 1222 | |
| 4. D.K. Metcalf, LAR | 1074 | |
| 5. Mecole Hardman, NYJ | 997 | |
League Leaders - Defense
| Tackles | Complete List | |
David Long
|
1. David Long, ARI | 81 |
| 2. Devin Bush, TB | 75 | |
| 3. Taylor Rapp, MIN | 49 | |
| 4. Amani Hooker, CHI | 43 | |
| 5. Julian Love, ATL | 42 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, LAC | 12 |
| 2. Gary Johnson, LAC | 8 | |
| 3. Josh Allen, DAL | 8 | |
| 4. Rashan Gary, OAK | 7 | |
| 5. Porter Gustin, ARI | 7 | |
| Interceptions | Complete List | |
Greedy Williams
|
1. Greedy Williams, NO | 4 |
| 2. Mack Wilson, KC | 2 | |
| 3. JoeJuan Williams, BAL | 2 | |
| 4. Devin Bush, TB | 2 | |
| 5. Juan Thornhill, TEN | 2 | |