League Leaders - Offense
| Passing Yards | Complete List | |
Cole McDonald
|
1. Cole McDonald, WAS | 4135 |
| 2. Jordan Love, GB | 3213 | |
| 3. Justin Herbert, LAC | 3126 | |
| 4. Joe Burrow, CIN | 2692 | |
| 5. Jalen Hurts, TEN | 2212 | |
| Rushing Yards | Complete List | |
J.K. Dobbins
|
1. J.K. Dobbins, BAL | 670 |
| 2. Clyde Edwards-Helaire, KC | 584 | |
| 3. D'Andre Swift, DET | 553 | |
| 4. Jonathan Taylor, IND | 418 | |
| 5. Jalen Hurts, TEN | 206 | |
| Receiving Yards | Complete List | |
Henry Ruggs III
|
1. Henry Ruggs III, DEN | 1450 |
| 2. Jalen Reagor, PHI | 1275 | |
| 3. Denzel Mims, NYJ | 1200 | |
| 4. K.J. Hamler, WAS | 1018 | |
| 5. Jerry Jeudy, DEN | 763 | |
League Leaders - Defense
| Tackles | Complete List | |
Patrick Queen
|
1. Patrick Queen, BAL | 43 |
| 2. Javin White, SEA | 39 | |
| 3. Kenneth Murray Jr, LAC | 37 | |
| 4. Willie Gay, KC | 37 | |
| 5. Reggie Robinson II, DAL | 35 | |
| Sacks | Complete List | |
Chase Young
|
1. Chase Young, WAS | 13 |
| 2. Kenny Willekes, MIN | 9 | |
| 3. Terrell Lewis, DEN | 6 | |
| 4. Josh Uche, NE | 5 | |
| 5. Patrick Queen, BAL | 5 | |
| Interceptions | Complete List | |
Kenny Robinson Jr
|
1. Kenny Robinson Jr, DEN | 11 |
| 2. Terrell Burgess, LAR | 9 | |
| 3. Marc-Antoine Dequoy, BAL | 8 | |
| 4. Reggie Robinson II, DAL | 8 | |
| 5. Xavier McKinney, NYG | 8 | |