League Leaders - Offense
| Passing Yards | Complete List | |
Joe Burrow
|
1. Joe Burrow, BUF | 4947 |
| 2. Tua Tagovailoa, ARI | 4010 | |
| 3. Jacob Eason, HOU | 3961 | |
| 4. Jordan Love, LAC | 3906 | |
| 5. Justin Herbert, MIN | 3741 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, CLE | 804 |
| 2. D'Andre Swift, IND | 656 | |
| 3. Cam Akers, NYJ | 520 | |
| 4. JK Dobbins, CIN | 497 | |
| 5. Clyde Edwards-Helaire, CHI | 396 | |
| Receiving Yards | Complete List | |
Colby Parkinson
|
1. Colby Parkinson, BUF | 1390 |
| 2. Cole Kmet, JAX | 1311 | |
| 3. Thaddeus Moss, KC | 1203 | |
| 4. Henry Ruggs III, BAL | 1182 | |
| 5. Jalen Reagor, BUF | 1081 | |
League Leaders - Defense
| Tackles | Complete List | |
Isaiah Simmons
|
1. Isaiah Simmons, IND | 70 |
| 2. Kyle Dugger, MIA | 60 | |
| 3. Trevon Diggs, KC | 60 | |
| 4. Julian Okwara, TEN | 60 | |
| 5. Anfernee Jennings, ARI | 59 | |
| Sacks | Complete List | |
Patrick Queen
|
1. Patrick Queen, KC | 18 |
| 2. AJ Epenesa, MIA | 16 | |
| 3. Terrell Lewis, SEA | 12 | |
| 4. K'Lavon Chaisson, LAR | 12 | |
| 5. Josh Uche, TB | 11 | |
| Interceptions | Complete List | |
Trevon Diggs
|
1. Trevon Diggs, KC | 5 |
| 2. Kyle Dugger, MIA | 4 | |
| 3. Antoine Winfield, PHI | 3 | |
| 4. Isaiah Simmons, IND | 2 | |
| 5. Darnay Holmes, NYG | 2 | |