League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 2440 |
| 2. Dwayne Haskins Jr, WAS | 2073 | |
| 3. Nick Fitzgerald, TB | 1038 | |
| 4. Daniel Jones, NYG | 612 | |
| 5. Easton Stick, ATL | 104 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, OAK | 767 |
| 2. Justice Hill, BAL | 327 | |
| 3. Darrell Henderson Jr, LAR | 323 | |
| 4. Kyler Murray, ARI | 272 | |
| 5. Tony Pollard, DAL | 247 | |
| Receiving Yards | Complete List | |
Marquise Brown
|
1. Marquise Brown, BAL | 701 |
| 2. Parris Campbell, IND | 651 | |
| 3. Mecole Hardman, KC | 625 | |
| 4. J.J. Arcega-Whiteside, PHI | 423 | |
| 5. T.J. Hockenson, DET | 409 | |
League Leaders - Defense
| Tackles | Complete List | |
Germaine Pratt
|
1. Germaine Pratt, CIN | 41 |
| 2. Devin White, TB | 35 | |
| 3. Darnell Savage Jr, GB | 29 | |
| 4. DeAndre Baker, NYG | 25 | |
| 5. Bobby Okereke, IND | 23 | |
| Sacks | Complete List | |
Rashan Gary
|
1. Rashan Gary, GB | 7 |
| 2. Josh Allen, JAX | 5 | |
| 3. Nick Bosa, SF | 5 | |
| 4. Quinnen Williams, NYJ | 4 | |
| 5. Dexter Lawrence II, NYG | 4 | |
| Interceptions | Complete List | |
Joejuan Williams
|
1. Joejuan Williams, HOU | 9 |
| 2. Mack Wilson, CLE | 5 | |
| 3. Rock Ya-Sin, IND | 3 | |
| 4. Greedy Williams, CLE | 2 | |
| 5. Sean Murphy-Bunting, TB | 2 | |