League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, BUF | 1919 |
| 2. Sam Darnold, NYJ | 1918 | |
| 3. Lamar Jackson, BAL | 1915 | |
| 4. Baker Mayfield, CLE | 1833 | |
| 5. Josh Rosen, ARI | 1647 | |
| Rushing Yards | Complete List | |
Sony Michel
|
1. Sony Michel, NE | 536 |
| 2. Ronald Jones II, TB | 509 | |
| 3. Bo Scarbrough, DAL | 504 | |
| 4. Derrius Guice, WAS | 448 | |
| 5. Royce Freeman, DEN | 388 | |
| Receiving Yards | Complete List | |
Michael Gallup
|
1. Michael Gallup, DAL | 643 |
| 2. Calvin Ridley, ATL | 513 | |
| 3. Hayden Hurst, BAL | 362 | |
| 4. Courtland Sutton, DEN | 346 | |
| 5. Marquez Valdes-Scantling, GB | 331 | |
League Leaders - Defense
| Tackles | Complete List | |
Tremaine Edmunds
|
1. Tremaine Edmunds, BUF | 34 |
| 2. Marcus Davenport, NO | 28 | |
| 3. Rashaan Evans, TEN | 28 | |
| 4. Malik Jefferson, CIN | 24 | |
| 5. Minkah Fitzpatrick, MIA | 22 | |
| Sacks | Complete List | |
Marcus Davenport
|
1. Marcus Davenport, NO | 10 |
| 2. Bradley Chubb, DEN | 7 | |
| 3. Leon Jacobs, JAX | 4 | |
| 4. Chad Thomas, CLE | 3 | |
| 5. Jermaine Carter Jr, CAR | 2 | |
| Interceptions | Complete List | |
Roquan Smith
|
1. Roquan Smith, CHI | 3 |
| 2. Minkah Fitzpatrick, MIA | 2 | |
| 3. Armani Watts, KC | 2 | |
| 4. Denzel Ward, CLE | 2 | |
| 5. Micah Kiser, LAR | 2 | |