League Leaders - Offense
| Passing Yards | Complete List | |
Jayden Daniels
|
1. Jayden Daniels, TB | 3683 |
| 2. Randall Cunningham II, CLE | 3506 | |
| 3. Sam Howell, NE | 3035 | |
| 4. Jarret Doege, NO | 2551 | |
| 5. Kedon Slovis, JAX | 1323 | |
| Rushing Yards | Complete List | |
John Emery Jr
|
1. John Emery Jr, KC | 818 |
| 2. George Holani, LAC | 692 | |
| 3. Jerrion Ealy, LV | 649 | |
| 4. Zamir White, IND | 310 | |
| 5. Randall Cunningham II, CLE | 266 | |
| Receiving Yards | Complete List | |
Anthony Schwartz
|
1. Anthony Schwartz, CLE | 682 |
| 2. Cade Otton, HOU | 643 | |
| 3. George Pickens, MIA | 547 | |
| 4. John Emery Jr, KC | 499 | |
| 5. Justyn Ross, NE | 492 | |
League Leaders - Defense
| Tackles | Complete List | |
Jack Sanborn
|
1. Jack Sanborn, IND | 57 |
| 2. Shane Lee, LV | 52 | |
| 3. Derek Stingley, MIN | 50 | |
| 4. Anthony Cook, SEA | 42 | |
| 5. Daxton Hill, PHI | 40 | |
| Sacks | Complete List | |
Nolan Smith
|
1. Nolan Smith, BUF | 10 |
| 2. Devin Lloyd, PIT | 9 | |
| 3. Jordan Williams, NO | 4 | |
| 4. Xavier Thomas, CLE | 4 | |
| 5. Travon Walker, LV | 3 | |
| Interceptions | Complete List | |
Daxton Hill
|
1. Daxton Hill, PHI | 9 |
| 2. Jordan Battle, CLE | 7 | |
| 3. Pat Fields, GB | 6 | |
| 4. Kyle Hamilton, LAC | 4 | |
| 5. Shaun Davis, DET | 4 | |