League Leaders - Offense
| Passing Yards | Complete List | |
Justin Herbert
|
1. Justin Herbert, BKN | 4163 |
| 2. Phil Jurkovec, HST | 4058 | |
| 3. Kedon Slovis, CHI | 3987 | |
| 4. Aaron Rodgers, MIA | 3968 | |
| 5. Baker Mayfield, ATL | 3954 | |
| Rushing Yards | Complete List | |
Ronald Jones II
|
1. Ronald Jones II, SF | 1559 |
| 2. Saquon Barkley, HOU | 1342 | |
| 3. Najee Harris, LV | 1297 | |
| 4. Derrick Henry, PHI | 1287 | |
| 5. Isaiah Spiller, NO | 1287 | |
| Receiving Yards | Complete List | |
Marquise Brown
|
1. Marquise Brown, BKN | 1336 |
| 2. Jordan Whittington, GB | 1279 | |
| 3. Mecole Hardman, MEM | 1246 | |
| 4. Ja'Marr Chase, HOU | 1185 | |
| 5. Brandin Cooks, PIT | 1180 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Bolton
|
1. Nick Bolton, ARI | 91 |
| 2. Gabe Jones, LV | 91 | |
| 3. Noah Sewell, KC | 87 | |
| 4. Dre Greenlaw, TB | 86 | |
| 5. Eric Kendricks, SEA | 82 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, MIA | 21 |
| 2. DeMarcus Lawrence, DAL | 15 | |
| 3. Justin Egoigbe, IND | 13 | |
| 4. Micah Parsons, IND | 13 | |
| 5. Joey Bosa, CIN | 11 | |
| Interceptions | Complete List | |
Marshon Lattimore
|
1. Marshon Lattimore, CIN | 7 |
| 2. L'Jarius Sneed, NYJ | 7 | |
| 3. Kaiir Elam, MIA | 6 | |
| 4. Stephon Gilmore, IND | 6 | |
| 5. Budda Baker, LO2 | 6 | |