League Leaders - Offense
| Passing Yards | Complete List | |
DJ Uiagalelei
|
1. DJ Uiagalelei, TB | 3686 |
| 2. Bryce Young, HOU | 3525 | |
| 3. Hudson Card, WAS | 2903 | |
| 4. Haynes King, LV | 2269 | |
| 5. Jeff Sims, SEA | 10 | |
| Rushing Yards | Complete List | |
Zachary Evans
|
1. Zachary Evans, MIN | 851 |
| 2. Kevontre Bradford, NYJ | 674 | |
| 3. Tank Bigsby, PIT | 613 | |
| 4. EJ Smith, CHI | 363 | |
| 5. Haynes King, LV | 140 | |
| Receiving Yards | Complete List | |
Quentin Johnston
|
1. Quentin Johnston, TB | 880 |
| 2. Arean Smith, HOU | 647 | |
| 3. Rakim Jarrett, CIN | 553 | |
| 4. Xzavier Henderson, WAS | 539 | |
| 5. Kayshon Boutte, HST | 363 | |
League Leaders - Defense
| Tackles | Complete List | |
Noah Sewell
|
1. Noah Sewell, KC | 87 |
| 2. Jordan Toles, BKN | 59 | |
| 3. Elias Ricks, BKN | 59 | |
| 4. Sergio Allen, ATL | 57 | |
| 5. Kelee Ringo, SEA | 54 | |
| Sacks | Complete List | |
Drew Sanders
|
1. Drew Sanders, IND | 9 |
| 2. Damian Sellers, ARI | 5 | |
| 3. Bryan Bresee, LAC | 4 | |
| 4. Jalen Carter, NYJ | 4 | |
| 5. Myles Murphy, DEN | 3 | |
| Interceptions | Complete List | |
Jaylon Jones
|
1. Jaylon Jones, DET | 3 |
| 2. Avantae Williams, SF | 2 | |
| 3. Dontae Manning, ATL | 2 | |
| 4. Sergio Allen, ATL | 2 | |
| 5. Enzo Jennings, IND | 1 | |