League Leaders - Offense
| Passing Yards | Complete List | |
Baker Mayfield
|
1. Baker Mayfield, MIN | 1779 |
| 2. Deshaun Watson, TEN | 1699 | |
| 3. Trey Lance, NYJ | 1335 | |
| 4. Trevor Lawrence, BAL | 1324 | |
| 5. Duck Howard, PIT | 1309 | |
| Rushing Yards | Complete List | |
Travis Etienne Jr
|
1. Travis Etienne Jr, DET | 635 |
| 2. Dorian O'Daniel, NO | 506 | |
| 3. Saquon Barkley, JAX | 499 | |
| 4. Josh Jacobs, SEA | 472 | |
| 5. Jonathan Taylor, IND | 467 | |
| Receiving Yards | Complete List | |
Larry Johnson
|
1. Larry Johnson, NYJ | 698 |
| 2. Ihmir Smith-Marsette, MIN | 472 | |
| 3. Jerome Pritchett, MIN | 443 | |
| 4. Marquez Stevenson, TEN | 441 | |
| 5. Dicaprio Bootle, PIT | 427 | |
League Leaders - Defense
| Tackles | Complete List | |
Darrick Forrest
|
1. Darrick Forrest, NYG | 24 |
| 2. Devin White, CLE | 23 | |
| 3. Fred Warner, SF | 21 | |
| 4. Eric Pratt, CAR | 21 | |
| 5. Noah Igbinoghene, MIA | 21 | |
| Sacks | Complete List | |
Vernon Butler Jr
|
1. Vernon Butler Jr, BUF | 11 |
| 2. Ed Oliver, TEN | 7 | |
| 3. Julian Okwara, DET | 6 | |
| 4. Isaiah Booker, HOU | 5 | |
| 5. Joey Hartwell, ATL | 5 | |
| Interceptions | Complete List | |
Vontae Mack
|
1. Vontae Mack, BUF | 9 |
| 2. Julian Blackmon, IND | 8 | |
| 3. Tevan Ivory, GB | 6 | |
| 4. Justin Simmons, DEN | 5 | |
| 5. Isaiah Simmons, GB | 5 | |