League Leaders - Offense
| Passing Yards | Complete List | |
Justin Fields
|
1. Justin Fields, CHI | 5472 |
| 2. Trevor Lawrence, JAX | 4853 | |
| 3. Kellen Mond, NO | 4202 | |
| 4. Zach Wilson, NYJ | 4071 | |
| 5. Trey Lance, SF | 3930 | |
| Rushing Yards | Complete List | |
Michael Carter
|
1. Michael Carter, NYJ | 1764 |
| 2. Najee Harris, PIT | 1192 | |
| 3. Travis Etienne Jr, JAX | 1121 | |
| 4. Trey Sermon, SF | 928 | |
| 5. Chuba Hubbard, NYJ | 558 | |
| Receiving Yards | Complete List | |
Jaylen Waddle
|
1. Jaylen Waddle, MIA | 2077 |
| 2. Rondale Moore, ARI | 1678 | |
| 3. Kyle Pitts, ATL | 1520 | |
| 4. D'Wayne Eskridge, SEA | 1328 | |
| 5. Rashod Bateman, JAX | 1299 | |
League Leaders - Defense
| Tackles | Complete List | |
Jevon Holland
|
1. Jevon Holland, MIA | 59 |
| 2. Baron Browning, DEN | 58 | |
| 3. Isaiah McDuffie, GB | 57 | |
| 4. Asante Samuel Jr, LAC | 54 | |
| 5. Richie Grant, ATL | 54 | |
| Sacks | Complete List | |
Azeez Ojulari
|
1. Azeez Ojulari, NYG | 13 |
| 2. Jaelan Phillips, MIA | 8 | |
| 3. Odafe Oweh, BAL | 8 | |
| 4. Zaven Collins, ARI | 7 | |
| 5. Joe Tryon, TB | 6 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, DEN | 12 |
| 2. Shaun Wade, NYJ | 11 | |
| 3. Jaycee Horn, CAR | 10 | |
| 4. Eric Stokes, GB | 9 | |
| 5. Isaiah McDuffie, GB | 9 | |