League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 3011 |
| 2. Justin Herbert, NYG | 2889 | |
| 3. Joe Burrow, CIN | 2669 | |
| 4. Josh Allen, BUF | 2403 | |
| 5. Cody Boss, HOU | 2357 | |
| Rushing Yards | Complete List | |
Kenneth Walker III
|
1. Kenneth Walker III, SEA | 831 |
| 2. Breece Hall, NYJ | 819 | |
| 3. Barry Coakley, JAX | 798 | |
| 4. Sean Miner, DET | 795 | |
| 5. Saquon Barkley, NYG | 773 | |
| Receiving Yards | Complete List | |
Stephen Wilder
|
1. Stephen Wilder, ARI | 1377 |
| 2. Quez Watkins, CIN | 993 | |
| 3. Ja'Marr Chase, CIN | 945 | |
| 4. Danny Spencer, NYJ | 831 | |
| 5. Mecole Hardman, KC | 822 | |
League Leaders - Defense
| Tackles | Complete List | |
Victor Ash
|
1. Victor Ash, SF | 30 |
| 2. Lewis Cine, NYG | 28 | |
| 3. Derek Stingley Jr, PHI | 28 | |
| 4. Patrick Queen, NO | 27 | |
| 5. Troy Andersen, LV | 27 | |
| Sacks | Complete List | |
Josh Paschal
|
1. Josh Paschal, PHI | 12 |
| 2. Alex Highsmith, BUF | 11 | |
| 3. DeForest Buckner, NYG | 9 | |
| 4. George Karlaftis, KC | 9 | |
| 5. Trey Hendrickson, NE | 9 | |
| Interceptions | Complete List | |
Eric Stokes
|
1. Eric Stokes, GB | 11 |
| 2. Jaycee Horn, NYG | 11 | |
| 3. Kamren Curl, GB | 9 | |
| 4. Gill McClendon, KC | 8 | |
| 5. C.J. Gardner-Johnson, PHI | 8 | |