League Leaders - Offense
| Passing Yards | Complete List | |
Tim Griffin
|
1. Tim Griffin, LV | 3477 |
| 2. Tyson Bayless, NYJ | 3462 | |
| 3. Shane Leonard, IND | 3000 | |
| 4. Colin Austin, HOU | 2595 | |
| 5. Rashaad Jenkins, DEN | 2565 | |
| Rushing Yards | Complete List | |
James Carruthers
|
1. James Carruthers, GB | 1438 |
| 2. Shelton Sellers, LV | 478 | |
| 3. Brandon Lowe, MIA | 452 | |
| 4. Tyson Bayless, NYJ | 131 | |
| 5. Rick Mallard, BUF | 98 | |
| Receiving Yards | Complete List | |
Will Jeffries
|
1. Will Jeffries, IND | 1251 |
| 2. Evan Platt, TB | 1122 | |
| 3. Damion Stoudemire, CIN | 802 | |
| 4. Tavon Bonds, BUF | 706 | |
| 5. Glenn Wallace, IND | 381 | |
League Leaders - Defense
| Tackles | Complete List | |
Collin Morgan
|
1. Collin Morgan, TEN | 54 |
| 2. Gordon Morris, PIT | 51 | |
| 3. Pat Elam, PIT | 48 | |
| 4. Isaiah Callahan, KC | 48 | |
| 5. Lamar Cumberland, BUF | 40 | |
| Sacks | Complete List | |
Jarez Dillon
|
1. Jarez Dillon, DAL | 5 |
| 2. Leon Darby, SF | 4 | |
| 3. Collin Morgan, TEN | 3 | |
| 4. Jimmy Linton, PIT | 3 | |
| 5. Clifton Roby, BAL | 2 | |
| Interceptions | Complete List | |
Isaiah Callahan
|
1. Isaiah Callahan, KC | 6 |
| 2. Collin Morgan, TEN | 6 | |
| 3. Donovan Baber, NE | 5 | |
| 4. Reggie Kilgore, DEN | 4 | |
| 5. Rashaud Lowry, NYJ | 4 | |