League Leaders - Offense
| Passing Yards | Complete List | |
Josh Rosen
|
1. Josh Rosen, ARI | 3628 |
| 2. Lamar Jackson, BAL | 3501 | |
| 3. Sam Darnold, NYJ | 3251 | |
| 4. Baker Mayfield, CLE | 2565 | |
| 5. Josh Allen, BUF | 2456 | |
| Rushing Yards | Complete List | |
Ronald Jones II
|
1. Ronald Jones II, TB | 883 |
| 2. Saquon Barkley, NYG | 723 | |
| 3. Rashaad Penny, SEA | 650 | |
| 4. Derrius Guice, WAS | 507 | |
| 5. Royce Freeman, DEN | 460 | |
| Receiving Yards | Complete List | |
Calvin Ridley
|
1. Calvin Ridley, ATL | 652 |
| 2. Hayden Hurst, BAL | 645 | |
| 3. Christian Kirk, ARI | 643 | |
| 4. Courtland Sutton, DEN | 560 | |
| 5. Saquon Barkley, NYG | 491 | |
League Leaders - Defense
| Tackles | Complete List | |
Dorian O'Daniel
|
1. Dorian O'Daniel, KC | 52 |
| 2. Tremaine Edmunds, BUF | 50 | |
| 3. Darius Leonard, IND | 48 | |
| 4. Minkah Fitzpatrick, MIA | 39 | |
| 5. Leighton Vander Esch, DAL | 36 | |
| Sacks | Complete List | |
|
Dorian O'Daniel
|
1. Dorian O'Daniel, KC | 8 |
| 2. Maurice Hurst, OAK | 8 | |
| 3. Da'Ron Payne, WAS | 7 | |
| 4. Breeland Speaks, KC | 6 | |
| 5. Darius Leonard, IND | 4 | |
| Interceptions | Complete List | |
Jaire Alexander
|
1. Jaire Alexander, GB | 6 |
| 2. Minkah Fitzpatrick, MIA | 5 | |
| 3. Dorian O'Daniel, KC | 5 | |
| 4. Joel Iyiegbuniwe, CIN | 4 | |
| 5. Derwin James, LAC | 4 | |