League Leaders - Offense
| Passing Yards | Complete List | |
Justin Herbert
|
1. Justin Herbert, BUF | 3174 |
| 2. Drew Lock, IND | 2977 | |
| 3. Easton Stick, MIA | 2590 | |
| 4. Eric Dungey, MIN | 2355 | |
| 5. Jarrett Stidham, NYG | 939 | |
| Rushing Yards | Complete List | |
Benny Snell
|
1. Benny Snell, DEN | 522 |
| 2. Bryce Love, OAK | 478 | |
| 3. Damien Harris, SF | 323 | |
| 4. Justice Hill, DEN | 279 | |
| 5. Myles Gaskin, TEN | 266 | |
| Receiving Yards | Complete List | |
Lawrence Cager
|
1. Lawrence Cager, DET | 1367 |
| 2. Collin Johnson, MIA | 982 | |
| 3. AJ Brown, DAL | 840 | |
| 4. Karlos Howard, SF | 508 | |
| 5. Juwan Johnson, IND | 459 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TEN | 52 |
| 2. Tyrel Dodson, WAS | 47 | |
| 3. Devin Bush, OAK | 47 | |
| 4. Alex Briones, BUF | 38 | |
| 5. Cameron Smith, WAS | 37 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, KC | 17 |
| 2. Jalen Jelks, IND | 9 | |
| 3. Clelin Ferrell, CAR | 9 | |
| 4. Dexter Lawrence, GB | 7 | |
| 5. Rashan Gary, NYG | 7 | |
| Interceptions | Complete List | |
Josh Allen
|
1. Josh Allen, IND | 4 |
| 2. Shaquille Quarterman, ATL | 4 | |
| 3. Devin Bush, OAK | 4 | |
| 4. Iman Marshall, IND | 2 | |
| 5. Chase Hancock, LAC | 2 | |