League Leaders - Offense
| Passing Yards | Complete List | |
Deshaun Watson
|
1. Deshaun Watson, HOU | 1977 |
| 2. Mitchell Trubisky, CHI | 1780 | |
| 3. DeShone Kizer, CLE | 1627 | |
| 4. Patrick Mahomes II, KC | 827 | |
| 5. Cooper Rush, DAL | 454 | |
| Rushing Yards | Complete List | |
Leonard Fournette
|
1. Leonard Fournette, JAX | 1103 |
| 2. T.J. Logan, ARI | 755 | |
| 3. James Conner, PIT | 594 | |
| 4. Jamaal Williams, GB | 346 | |
| 5. Christian McCaffrey, CAR | 313 | |
| Receiving Yards | Complete List | |
Curtis Samuel
|
1. Curtis Samuel, CAR | 670 |
| 2. Bucky Hodges, MIN | 541 | |
| 3. Zach Conque, DEN | 410 | |
| 4. Evan Engram, NYG | 377 | |
| 5. David Njoku, CLE | 311 | |
League Leaders - Defense
| Tackles | Complete List | |
Marcus Maye
|
1. Marcus Maye, NYJ | 35 |
| 2. Marshon Lattimore, NO | 34 | |
| 3. Quincy Wilson, IND | 31 | |
| 4. Tre'Davious White, BUF | 31 | |
| 5. Adoree' Jackson, TEN | 29 | |
| Sacks | Complete List | |
Trey Hendrickson
|
1. Trey Hendrickson, NO | 11 |
| 2. Jonathan Allen, WAS | 11 | |
| 3. Nathan Gerry, NO | 7 | |
| 4. Solomon Thomas, SF | 6 | |
| 5. Tyus Bowser, BAL | 6 | |
| Interceptions | Complete List | |
Gareon Conley
|
1. Gareon Conley, OAK | 7 |
| 2. Jabrill Peppers, CLE | 6 | |
| 3. Brendan Langley, DEN | 4 | |
| 4. Kevin King, GB | 4 | |
| 5. Marshon Lattimore, NO | 4 | |
