League Leaders - Offense
| Passing Yards | Complete List | |
Trey Lance
|
1. Trey Lance, SF | 6654 |
| 2. Jordan Love, GB | 5732 | |
| 3. Mac Jones, NE | 5631 | |
| 4. Josh Allen, BUF | 5201 | |
| 5. Joe Burrow, CIN | 5179 | |
| Rushing Yards | Complete List | |
Jaden Hodge
|
1. Jaden Hodge, SF | 2114 |
| 2. Joe Mixon, CIN | 2105 | |
| 3. Kareem Hunt, NYJ | 1947 | |
| 4. Nick Chubb, CLE | 1918 | |
| 5. Najee Harris, PIT | 1771 | |
| Receiving Yards | Complete List | |
D.J. Chark Jr
|
1. D.J. Chark Jr, SF | 2341 |
| 2. Jalen Chapman, SF | 2130 | |
| 3. Tyreek Hill, NE | 1865 | |
| 4. Darnell Mooney, CHI | 1770 | |
| 5. Ja'Marr Chase, CIN | 1533 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 118 |
| 2. Alexander Johnson, HOU | 99 | |
| 3. Leighton Vander Esch, TEN | 94 | |
| 4. Max Cone, SEA | 87 | |
| 5. Dre Greenlaw, ATL | 86 | |
| Sacks | Complete List | |
Maxx Crosby
|
1. Maxx Crosby, BAL | 34 |
| 2. Brian Burns, CAR | 21 | |
| 3. Myles Garrett, CLE | 16 | |
| 4. Jaelan Phillips, MIA | 16 | |
| 5. Aaron Donald, WAS | 15 | |
| Interceptions | Complete List | |
Donte Jackson
|
1. Donte Jackson, CAR | 12 |
| 2. Kendall Fuller, JAX | 10 | |
| 3. Eric Stokes, GB | 10 | |
| 4. Noah Igbinoghene, MIA | 9 | |
| 5. Jeremy Chinn, CAR | 9 | |