League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 4815 |
| 2. Trey Lance, SF | 4409 | |
| 3. Ricky Hunt, DET | 4378 | |
| 4. Justin Fields, CHI | 4290 | |
| 5. Deshaun Watson, HOU | 4087 | |
| Rushing Yards | Complete List | |
Christian McCaffrey
|
1. Christian McCaffrey, CAR | 1606 |
| 2. Derrick Henry, TEN | 1596 | |
| 3. Ezekiel Elliott, DAL | 1212 | |
| 4. Lonnie Rush, SF | 1099 | |
| 5. Najee Harris, PIT | 1069 | |
| Receiving Yards | Complete List | |
Josh Bright
|
1. Josh Bright, KC | 1944 |
| 2. Nate Woodard, SF | 1503 | |
| 3. Anthony Schwartz, CLE | 1428 | |
| 4. Darnell Mooney, CHI | 1347 | |
| 5. Marquez Valdes-Scantling, GB | 1346 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Kwiatkoski
|
1. Nick Kwiatkoski, LV | 63 |
| 2. Kamu Grugier-Hill, HOU | 61 | |
| 3. Jamin Davis, WAS | 58 | |
| 4. Shaq Thompson, CAR | 55 | |
| 5. Bobby Wagner, SEA | 54 | |
| Sacks | Complete List | |
Brian Burns
|
1. Brian Burns, CAR | 22 |
| 2. Chase Young, WAS | 13 | |
| 3. DeMarcus Lawrence, DAL | 13 | |
| 4. Jaelan Phillips, MIA | 12 | |
| 5. Allen Bird, CAR | 12 | |
| Interceptions | Complete List | |
Michael Davis
|
1. Michael Davis, SF | 15 |
| 2. Derwin James Jr, BUF | 11 | |
| 3. Kelvin Joseph, DAL | 10 | |
| 4. Leighton Vander Esch, TEN | 10 | |
| 5. Isaiah Johnson, MIA | 10 | |