League Leaders - Offense
| Passing Yards | Complete List | |
Dalton Purcell
|
1. Dalton Purcell, TB | 1479 |
| 2. Conner Librizzi, MIA | 1316 | |
| 3. Justin Fields, CHI | 1279 | |
| 4. Justin Herbert, LAC | 1226 | |
| 5. Lamar Jackson, BAL | 1186 | |
| Rushing Yards | Complete List | |
Tanner Green
|
1. Tanner Green, NYJ | 522 |
| 2. Brennon Young, NE | 514 | |
| 3. Simon Gingras-Gagnon, HOU | 423 | |
| 4. Tyrion Davis-Price, TEN | 422 | |
| 5. James Cook, ATL | 382 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, KC | 516 |
| 2. Marquise Brown, BAL | 435 | |
| 3. Davante Adams, HOU | 421 | |
| 4. Tyquan Thornton, NE | 414 | |
| 5. Keenan Allen, TB | 379 | |
League Leaders - Defense
| Tackles | Complete List | |
Kenneth Murray Jr
|
1. Kenneth Murray Jr, LAC | 40 |
| 2. Fred Warner, SF | 31 | |
| 3. Deion Jones, ATL | 31 | |
| 4. Eric Kendricks, MIN | 27 | |
| 5. Devin White, TB | 24 | |
| Sacks | Complete List | |
Ingimar Cyrusdottir
|
1. Ingimar Cyrusdottir, MIN | 8 |
| 2. Jermaine Johnson II, CHI | 7 | |
| 3. Rashan Gary, GB | 7 | |
| 4. LaBryan Ray, MIA | 7 | |
| 5. Omari Abor, TB | 6 | |
| Interceptions | Complete List | |
Eddie Jackson
|
1. Eddie Jackson, CHI | 4 |
| 2. Tre'Davious White, BUF | 3 | |
| 3. Jay Hudson, TEN | 3 | |
| 4. Xavier Nwankpa, CHI | 3 | |
| 5. Justin Reid, HOU | 3 | |