League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, BUF | 5031 |
| 2. D.J. Uiagalelei, CIN | 4692 | |
| 3. Trevor Lawrence, JAX | 4585 | |
| 4. JT Daniels, PIT | 4558 | |
| 5. Joe Milton, DEN | 4453 | |
| Rushing Yards | Complete List | |
Ezekiel Elliott
|
1. Ezekiel Elliott, DAL | 1799 |
| 2. Derrick Henry, TEN | 1738 | |
| 3. Najee Harris, PIT | 1571 | |
| 4. Antonio Gibson, WAS | 1452 | |
| 5. Jonathan Taylor, IND | 1357 | |
| Receiving Yards | Complete List | |
Dawson Knox
|
1. Dawson Knox, BUF | 1939 |
| 2. O.J. Howard, TB | 1674 | |
| 3. Garrett Wilson, DET | 1636 | |
| 4. Jalen Reagor, PHI | 1417 | |
| 5. Mecole Hardman, KC | 1396 | |
League Leaders - Defense
| Tackles | Complete List | |
Jaquiski Tartt
|
1. Jaquiski Tartt, CAR | 66 |
| 2. Juanyeh Thomas, MIA | 63 | |
| 3. Payton Wilson, GB | 62 | |
| 4. Eric Wilson, SEA | 62 | |
| 5. Devin White, TB | 61 | |
| Sacks | Complete List | |
Boye Mofe
|
1. Boye Mofe, PHI | 16 |
| 2. Azur Kamara, KC | 15 | |
| 3. Brian Burns, CAR | 15 | |
| 4. Josh Sweat, PHI | 15 | |
| 5. Trey Hendrickson, CIN | 11 | |
| Interceptions | Complete List | |
Juanyeh Thomas
|
1. Juanyeh Thomas, MIA | 12 |
| 2. Jeff Okudah, DET | 12 | |
| 3. Andrew Booth Jr, PHI | 11 | |
| 4. L'Jarius Sneed, KC | 11 | |
| 5. Darius Slay Jr, PHI | 11 | |