League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, JAX | 4403 |
| 2. Justin Fields, CHI | 3925 | |
| 3. Davis Mills, HOU | 3815 | |
| 4. Zach Wilson, NYJ | 3472 | |
| 5. Mac Jones, NE | 2583 | |
| Rushing Yards | Complete List | |
Michael Carter
|
1. Michael Carter, NYJ | 1344 |
| 2. Trey Sermon, SF | 754 | |
| 3. Najee Harris, PIT | 743 | |
| 4. Javonte Williams, DEN | 515 | |
| 5. Elijah Mitchell, SF | 347 | |
| Receiving Yards | Complete List | |
Kyle Pitts
|
1. Kyle Pitts, ATL | 1334 |
| 2. Jacob Harris, LAR | 1206 | |
| 3. Jaylen Waddle, MIA | 1152 | |
| 4. Nico Collins, HOU | 1072 | |
| 5. Ja'Marr Chase, CIN | 1070 | |
League Leaders - Defense
| Tackles | Complete List | |
Jevon Holland
|
1. Jevon Holland, MIA | 60 |
| 2. Andre Cisco, JAX | 45 | |
| 3. Jamin Davis, WAS | 42 | |
| 4. Micah Parsons, DAL | 41 | |
| 5. Tyson Campbell, JAX | 40 | |
| Sacks | Complete List | |
Kwity Paye
|
1. Kwity Paye, IND | 10 |
| 2. Patrick Surtain II, DEN | 3 | |
| 3. Levi Onwuzurike, DET | 3 | |
| 4. Jaelan Phillips, MIA | 3 | |
| 5. Michael Carter II, NYJ | 3 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, DEN | 8 |
| 2. Jevon Holland, MIA | 7 | |
| 3. Eric Stokes, GB | 6 | |
| 4. Trevon Moehrig, LV | 6 | |
| 5. Greg Newsome II, CLE | 5 | |